The GX 460 is excellent. It’s basically a Lexus 4Runner. But with much more luxury, and bells and whistles. It has a V8 engine. The ride is much nicer. And, like the 4Runner, the 460 is made in Japan. 

If you are not a Lexus mechanic, I suggest you get a late model RX 350, not an F-Sport, certified pre-owned 1 owner, and not by a rental car company. The CarFax will show if it was owned by a rental company or not. Best SUV in the World; unless you need a third row, then the GX460 is the best for a used SUV.

Nothing wrong with an F Sport, why xmistarks says no to one is beyond me. I have a 14 RX with 54k miles and nothing has been repaired since new. Carfax is good but, it's also important to check vin # through a Lexus service dept. Carfax can miss sometimes on dealer service history. Buy the best used RX you can afford.