My friend has a 2006 Honda Odyssey. A couple weeks ago, his door key wouldn't work. He was able to get in and drive it but the alarm kept going off. He had the lock cylinder repaired. Then the ignition switch had the same problem, and he had that cylinder repaired. I don't know if if that is related, but now he is having another problem. Sometimes the van will not start. Other times it will start and run while in park, even for quite a long time. But as soon as he tries to put it in gear, the van shakes and cuts out. He has replaced the fuel pump but that did not help.  The fi ecu fuse has also blown a few times.  Any idea what the problem is?

Thank you!