It depends on what you're going to do.  If you have an automatic transmission, the higher gear ration (lower number) caused by the larger diameter tires will put more of a strain on the trans.  The lift kit will alter the design geometry of the drive shaft(s) and may need to be compensated for with a transfer case drop kit.  There are lots of unintended consequences that need to be researched before making this decision.  Good luck. 

I suggest you join this forum for more specific information. Toyota 4Runner Forum - Largest 4Runner Forum - Powered by vBulletin (toyota-4runner.org)

Like Doc said, lifting it will cause you to have to address various issues that will result from the lift. A lot of guys lift their 4Runners but I have chosen to keep my 2019 ORP stock. I don't do any rock crawling or other extreme stuff.

People do it.

Just understand that your wallet will be entering a world of hurt. It doesn't end at lift and tires.

Get an older beater one and do these mods if you want to.