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Wha..

Gas mileage will probably get worse.
the engine will continue to compress that cylinder. But without fuel, no ignition, no boom, no power. Lost energy 😕
{black}:idontknow:
They've been working on this problem for ages. If it was that easy ...
If it were that simple, automakers wouldn’t have gone through all the trouble with a complex technology called cylinder deactivation which does more than just “turn off” the fuel to that cylinder(s). And look at the measly fuel savings owners are getting in real life.
No.
If I understand your question, you want to increase your fuel mileage by decreasing your fuel usage.
Say its a 4 cylinder. You disconnect one injector. No fuel is going to that cylinder but the piston is still moving in it.
Simple logic suggest, 4 cycle=one power stroke every 90 degrees.
Block one cylinder from firing and you have, bang,bang,pause,bang.
I should thing everything would be thrown out of wack by doing that.

