If the kids are small (shorter than, say, 5'3" for the next few years), the best deals to be had are not on CUVs, but hatchbacks. You have almost as much cargo space and the fuel economy and handling are much better too. Mazda 3 is the nicest one in that niche imho, but Honda Civic is the value leader. Can't go wrong with either one (although I just remembered that the 1.5 liter Honda engine had some oil dilution issues, so if it were me, I'd narrow it down to the Mazda or look at the non-turbo Honda).

It depends on a lot of factors, such as what your preferences are, what do you want, what features you may want/expect, you financial resources available for vehicle purchase including trade-in value of your existing vehicle. Also, your location can be a major factor, such as do you operate in snowy/icy conditions in winter, or do you operate in warmer southern climates. But without further details, I would start with a Toyota Camry, and 2016 is a particularly good year for used Camry's with low miles. Another good choice may be a Honda Accord 2015 or newer (4 cylinder, not V6), but for your family and the request for more space, I wouldn't consider a Civic. I would avoid Nissan, after 3-4 years reliability goes through the floor. Also, older Hyundai's and Kia's have lots of quality and reliability issues, even when new ! Family vehicles from GM can be a crap-shoot: sometimes you get lucky and find a good one, usually you get stuck with a money pit.

But then again, it's hard to make meaningful recommendations without more information.

The Toyota Sienna's are always a good choice. 

Sooo many things to consider (budget, traveling, commuting, carrying capacity). Plus you need to enjoy driving it in that way you will take great care of it. While Highlanders and Pilots are great they are big. Rav4 or a CRV are good choices as well. You just need to prioritize your needs.

Thanks for all your recommendations. Let me try to be more specific.  I am looking for an used car under 10k for a family of 4. My wife complains a lot about the harsh ride of the Matrix. It needs to be reliable and dependable for long and short trips.  Camry or Rav 4 is the obviously choice but would like to hear others opinions. thx!

I'd say if you want space and reliability, either a new or gently used Sienna van might work.  If you don't want a van, maybe a Highlander or possibly a RAV4 (if you want to stay within the Toyota brand).

It depends on many things, how much can you afford or want to pay, what type of class of vehicle are you looking for, and what things you use your vehicle for. If you can afford a Toyota than that is what you should get, just avoid the 2.4L Inline 4 cylinder Toyota's as they have an oil consumption problem.  

We have 2 Honda Accord that have been reliable, roomy, comfortable, and dare I say Sporty (fast) family cars.  Both 4 cylinders.

😁